The article discusses the most pressing problems of reducing the quality of some components of the environment (natural) in federal districts — macroregions of the Russian Federation, which require their solution. An analysis of the level of atmospheric air pollution by emissions of harmful and polluting substances from stationary sources, based on data from annual state statistical reporting, showed that over the previous 11 years, the minimum volume of emissions was noted in the North Caucasus macroregion, and the maximum in the Siberian macroregion. The next one is the problem of pollution of the seas of the Arctic Ocean with wastewater from Russian rivers flowing into these seas, containing such a substance that pollutes the water basin of the entire planet as microplastic. The largest volume of such polluted waters was noted in the Arkhangelsk region (Northwestern macroregion), Krasnoyarsk region and Tomsk region (Siberian macroregion), and the smallest in the Kostroma region (Central macroregion) and the Republic of Tyva (Siberian macroregion). The problem of preserving and restoring such a component of the natural environment as forests, including in the protected zone of Lake Baikal and the volcanoes of the Kamchatka Peninsula, is debatable. An analysis of plans for the construction of several waste processing complexes and waste processing plants in the North-Western macroregion is aimed at identifying possibilities for solving the problem of a future reduction in the volume of such a component of the natural environment as anthropogenic waste. To solve some problems, the authors propose specific measures.