descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2009 English Publisher:Informa UK LimitedJournal:Cancer Investigation, volume 27, pages 313-323 (issn: 0735-7907, eissn: 1532-4192,

Authors: HanByoul, Cho; Eun Suk, Kang; Young Tae, Kim; Jae-Hoon, Kim;

doi: 10.1080/07357900802375738

pmid: 19194826

Diagnostic and Prognostic Impact of Osteopontin Expression in Endometrial Cancer

- Summary
- Subjects
- Metrics

Abstract

The role of osteopontin as a biomarker in endometrial cancer has not been conclusively established. We evaluated the expression and potential of osteopontin as a biomarker for endometrial cancer. Real-time polymerase chain reaction and immunohistochemistry revealed osteopontin overexpression in endometrial cancer. The plasma osteopontin level in endometrial cancer was significantly higher than in healthy controls (P< 0.001). In FIGO stage I endometrial cancer, osteopontin correctly identified 18 of 29 cases (62.1%) that were not detected by CA125. By Cox multivariate analysis, osteopontin positivity was an independent prognostic factor for disease-free survival (hazard ratio = 3.18, P= 0.035).

Related Organizations

Yonsei University
Korea (Republic of)
Yonsei University Health System
Korea (Republic of)
Sungkyunkwan University
Korea (Republic of)
Samsung Medical Center
Korea (Republic of)
Severance Hospital
Korea (Republic of)

View all View all

Keywords

Adult, Endometrial Neoplasms/mortality, Tumor/blood*, 610, Polymerase Chain Reaction, Osteopontin/genetics, Osteopontin (OPN), Osteopontin/analysis, Biomarkers, Tumor, Humans, CA-125 Antigen/blood, Aged, Proportional Hazards Models, Osteopontin/blood*, diagnostic marker, Middle Aged, Prognosis, Immunohistochemistry, Endometrial Neoplasms, CA-125 Antigen, endometrial cancer, Endometrial Neoplasms/diagnosis*, Female, Osteopontin, Biomarkers, prognostic marker

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	14
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%