Anti-cancer activities of allyl isothiocyanate and its conjugated silicon quantum dots
Copyright policy )Anti-cancer activities of allyl isothiocyanate and its conjugated silicon quantum dots
AbstractAllyl isothiocyanate (AITC), a dietary phytochemical in some cruciferous vegetables, exhibits promising anticancer activities in many cancer models. However, previous data showed AITC to have a biphasic effect on cell viability, DNA damage and migration in human hepatoma HepG2 cells. Moreover, in a 3D co-culture of HUVEC with pericytes, it inhibited tube formation at high doses but promoted this at low doses, which confirmed its biphasic effect on angiogenesis. siRNA knockdown of Nrf2 and glutathione inhibition abolished the stimulation effect of AITC on cell migration and DNA damage. The biological activity of a novel AITC-conjugated silicon quantum dots (AITC-SiQDs) has been investigated for the first time. AITC-SiQDs showed similar anti-cancer properties to AITC at high doses while avoiding the low doses stimulation effect. In addition, AITC-SiQDs showed a lower and long-lasting activation of Nrf2 translocation into nucleus which correlated with their levels of cellular uptake, as detected by the intrinsic fluorescence of SiQDs. ROS production could be one of the mechanisms behind the anti-cancer effect of AITC-SiQDs. These data provide novel insights into the biphasic effect of AITC and highlight the application of nanotechnology to optimize the therapeutic potential of dietary isothiocyanates in cancer treatment.
- University of Aberdeen United Kingdom
- University of East Anglia United Kingdom
Physiologic/drug effects, Silicon, Cell Survival, NF-E2-Related Factor 2, 610, Neovascularization, Physiologic, Cell Movement/drug effects, Antineoplastic Agents, Apoptosis, R Medicine, Silicon/chemistry, Article, Cell Line, Cell Proliferation/drug effects, SDG 3 - Good Health and Well-being, Reactive Oxygen Species/metabolism, Cell Movement, Isothiocyanates, NF-E2-Related Factor 2/metabolism, Cell Line, Tumor, Antineoplastic Agents/chemistry, Quantum Dots, Humans, Isothiocyanates/chemistry, Quantum Dots/chemistry, Neovascularization, Cell Proliferation, Tumor, Apoptosis/drug effects, R, 540, Reactive Oxygen Species, Cell Survival/drug effects
Physiologic/drug effects, Silicon, Cell Survival, NF-E2-Related Factor 2, 610, Neovascularization, Physiologic, Cell Movement/drug effects, Antineoplastic Agents, Apoptosis, R Medicine, Silicon/chemistry, Article, Cell Line, Cell Proliferation/drug effects, SDG 3 - Good Health and Well-being, Reactive Oxygen Species/metabolism, Cell Movement, Isothiocyanates, NF-E2-Related Factor 2/metabolism, Cell Line, Tumor, Antineoplastic Agents/chemistry, Quantum Dots, Humans, Isothiocyanates/chemistry, Quantum Dots/chemistry, Neovascularization, Cell Proliferation, Tumor, Apoptosis/drug effects, R, 540, Reactive Oxygen Species, Cell Survival/drug effects
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