This study proposes a method of designing quadratic optimal fuzzy parallel-distributed-compensation controllers for a class of time-varying Takagi–Sugeno fuzzy model–based time-delay control systems used to solve the finite-horizon optimal control problem. The proposed method fuses the orthogonal function approach and the improved hybrid Taguchi-genetic algorithm. The Taguchi-genetic algorithm only requires algebraic computation to perform the algorithm used to solve time-varying Takagi–Sugeno fuzzy model–based time-delay feedback dynamic equations. The fuzzy parallel-distributed-compensation controller design problem is simplified by using the Taguchi-genetic algorithm to transform the static parameter optimization problem into an algebraic equation. The static optimization problem can then be solved easily by using the improved hybrid Taguchi-genetic algorithm to find the quadratic optimal parallel-distributed-compensation controllers of the time-varying Takagi–Sugeno fuzzy model–based time-delay control systems. The applicability of the proposed integrative method is demonstrated in a real-world design problem.