The path planning of anti-ship missile should be considered both cruising in safety and striking in quick, which is an intractable problem. In particular, it is difficult to consider the safety of each missile path in the path planning of multiple missiles. To solve this problem, the “AREA Algorithm” is presented to divide the relative relations of areas：relative security area of the threat areas and fast-attack area of target approaching. Specifically，it is a way to achieve area division through the relationship between the target and the center of the operational area. The Voronoi diagram topology network, Dijkstra algorithm and binary tree algorithm have been used in the above process as well. Finally, Simulations have verified the feasibility and obvious advantages of “AREA Algorithm” compared with the single algorithm, and the tactical meaning in path planning of multiple missiles.