Estrogen deficiency is the main cause of menopausal symptoms of varying intensity. Administration of vitamin and mineral supplements is a part of nonhormonal drug therapy and an etiopathologically substantiated method of therapy. Improving energy supply in cells and increasing the level of cyclic adenosine monophosphate (cAMP) can alter receptor sensitivity and amplify expression of estrogen effects without increasing their synthesis. Vitamins A and D affect gene transcription resulting in changes in synthesis of proteins which realize various biological potentials. The vast majority of women surveyed (70-80%) in the territory of the Russian Federation suffer from poly-hypovitaminoses, no matter their age, season, place of residence or professional affiliation. Additional supplementation with micronutrients has a positive effect on the body's defense system by stimulating non-specific resistance reactions, and that is key for the prevention of various diseases in the period of waning reproductive function.