Cell Therapy with Human Reprogrammed CD8+ T-Cells Has Antimetastatic Effects on Lewis Lung Carcinoma in C57BL/6 Mice
Copyright policy )Cell Therapy with Human Reprogrammed CD8+ T-Cells Has Antimetastatic Effects on Lewis Lung Carcinoma in C57BL/6 Mice
Using a model of Lewis lung carcinoma (LLC) in vitro and in vivo, we previously demonstrated increased antitumor activity in CD8+ T-cells reprogrammed with an MEK inhibitor and PD-1 blocker. In this follow-up study, we carried out the reprogramming of human CD8+ T-cells (hrT-cell) using the MEK inhibitor and PD-1 blocker and targeted LLC cells. The effects of hrT-cell therapy were studied in a mouse model of spontaneous metastasis of a solid LLC tumor. We found antimetastatic activity of hrT-cells, a decrease in the number of cancer cells and cancer stem cells in the lungs, and an increase in the number of T-cells in the blood (including effector T-cells). Thus, reprogramming of human CD8+ T-cells with an MEK inhibitor and PD-1 blocker with targeted training by tumor target cells is a potential platform for developing a new approach to targeted lung cancer therapy.
- National Research University of Electronic Technology Russian Federation
- Ministry of Health Russian Federation
- Siberian State Medical University (Tomsk) Russian Federation
- Siberian State Medical University Russian Federation
- Research Institute of Mental Health Russian Federation
Mitogen-Activated Protein Kinase Kinases, Lung Neoplasms, Льюиса карцинома легких, human reprogrammed CD8<sup>+</sup> T-cells; Lewis lung carcinoma; C57BL/6 mice; xenotransplantation; antimetastatic activity, Programmed Cell Death 1 Receptor, мыши, CD8-Positive T-Lymphocytes, ксенотрансплантация, Article, перепрограммирование, Mice, Inbred C57BL, Mice, Carcinoma, Lewis Lung, CD8+Т-клетки, антиметастатическая активность, Animals, Humans, Follow-Up Studies
Mitogen-Activated Protein Kinase Kinases, Lung Neoplasms, Льюиса карцинома легких, human reprogrammed CD8<sup>+</sup> T-cells; Lewis lung carcinoma; C57BL/6 mice; xenotransplantation; antimetastatic activity, Programmed Cell Death 1 Receptor, мыши, CD8-Positive T-Lymphocytes, ксенотрансплантация, Article, перепрограммирование, Mice, Inbred C57BL, Mice, Carcinoma, Lewis Lung, CD8+Т-клетки, антиметастатическая активность, Animals, Humans, Follow-Up Studies
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