The article presents preliminary results of the study and characterization of the neotectonic processes manifestations in Denisova Cave, their influence on the formation and post-sedimentation changes of Pleistocene cave deposits. In Denisova Cave, traces of paleoearthquakes are examined in sections of sedimentary strata of the Main, East and South Chambers. The main types of earthquakeinduced deformations are described. A chronological assessment of the episodes of ancient seismic events recorded in the stratigraphic sequence of the cave is given. It was established that as a result of seismic deformations, the displacements of the layers turned out to be insignificant and their boundaries are well correlated. There was no mixing of the substance of different lithological units and, accordingly, the archaeological finds and paleontological material contained in them. We also assume that neotectonic activity could have infl uenced the living conditions of primitive man as one of the environmental factors.