A case series of children and young people admitted to a tertiary care hospital in Germany with COVID-19
Copyright policy )A case series of children and young people admitted to a tertiary care hospital in Germany with COVID-19
Abstract Background While our knowledge about COVID-19 in adults has rapidly increased, data on the course of disease and outcome in children with different comorbidities is still limited. Methods Prospective, observational study at a tertiary care children’s hospital in southern Germany. Clinical and virology data from all paediatric patients admitted with SARS-CoV-2 infection at our hospital were prospectively assessed. Results Between March and November 2020, 14 patients were admitted with COVID-19. One patient was admitted a second time with COVID-19 6 months after initial disease. Among seven patients with severe underlying comorbidities, three developed multisystem inflammatory syndrome (MIS-C), two were admitted to the paediatric intensive care unit. One patient needed invasive ventilation. Another patient died shortly after discharge of COVID-19-related complications. Conclusions While COVID-19 generally causes mild disease in children, severe respiratory illness and MIS-C occur, in some cases with fatal outcome. Children with underlying diseases might be at special risk for severe disease.
- Heinrich Heine University Düsseldorf Germany
- Boston Children's Hospital United States
- Universitätsklinikum Tübingen Germany
- Universitätsklinikum Magdeburg Germany
- University of Duesseldorf Germany
Male, Adolescent, Infectious and parasitic diseases, RC109-216, Comorbidity, Intensive Care Units, Pediatric, Tertiary Care Centers, COVID-19 ; Systemic Inflammatory Response Syndrome/diagnosis [MeSH] ; Hospitalization [MeSH] ; Tertiary Care Centers [MeSH] ; Inpatients ; Intensive Care Units, Pediatric [MeSH] ; SARS-CoV-2/isolation ; Infant [MeSH] ; Male [MeSH] ; Comorbidity [MeSH] ; Child [MeSH] ; Research Article ; COVID-19/diagnosis [MeSH] ; Adolescent [MeSH] ; Female [MeSH] ; COVID-19/virology [MeSH] ; Humans [MeSH] ; Prospective Studies [MeSH] ; Viral diseases ; Children ; Germany [MeSH] ; SARS CoV-2 infection ; Comorbidity ; Child, Preschool [MeSH], Germany, Humans, Prospective Studies, Child, Children, Inpatients, SARS-CoV-2, COVID-19, Infant, Systemic Inflammatory Response Syndrome, Hospitalization, Child, Preschool, Female, SARS CoV-2 infection, Research Article
Male, Adolescent, Infectious and parasitic diseases, RC109-216, Comorbidity, Intensive Care Units, Pediatric, Tertiary Care Centers, COVID-19 ; Systemic Inflammatory Response Syndrome/diagnosis [MeSH] ; Hospitalization [MeSH] ; Tertiary Care Centers [MeSH] ; Inpatients ; Intensive Care Units, Pediatric [MeSH] ; SARS-CoV-2/isolation ; Infant [MeSH] ; Male [MeSH] ; Comorbidity [MeSH] ; Child [MeSH] ; Research Article ; COVID-19/diagnosis [MeSH] ; Adolescent [MeSH] ; Female [MeSH] ; COVID-19/virology [MeSH] ; Humans [MeSH] ; Prospective Studies [MeSH] ; Viral diseases ; Children ; Germany [MeSH] ; SARS CoV-2 infection ; Comorbidity ; Child, Preschool [MeSH], Germany, Humans, Prospective Studies, Child, Children, Inpatients, SARS-CoV-2, COVID-19, Infant, Systemic Inflammatory Response Syndrome, Hospitalization, Child, Preschool, Female, SARS CoV-2 infection, Research Article
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