In today’s digitalized educational landscape, the intelligent use of information is essential for personalizing learning, improving assessment accuracy, and supporting data-driven pedagogical decisions. This systematic review examines the integration of Application Programming Interfaces (APIs) powered by Artificial Intelligence (AI) to enhance educational information management and learning processes. A total of 27 peer-reviewed studies published between 2013 and 2025 were analyzed. First, a general description of the selected works was provided, followed by a breakdown by dimensions in order to identify recurring patterns, stated interests and gaps in the current scientific literature on the use of AI-driven APIs in Education. The findings highlight five main benefits: data interoperability, personalized learning, automated feedback, real-time student monitoring, and predictive performance analytics. All studies addressed personalization, 74.1% focused on platform integration, and 37% examined automated feedback. Reported outcomes include improvements in engagement (63%), comprehension (55.6%), and academic achievement (48.1%). However, the review also identifies concerns about privacy, algorithmic bias, and limited methodological rigor in existing research. The study concludes with a conceptual model that synthesizes these findings from pedagogical, technological, and ethical perspectives, providing guidance for more adaptive, inclusive, and responsible uses of AI in education.