ObjectiveTo determine the impacts of climate variability on foodborne diarrhoeal disease worldwide.MethodsThis work was performed based on PRISMA guideline. Articles were retrieved from the PubMed, MEDLINE, Web of Science, Scopus, DOAJ, and Google Scholar. The search was made using Boolean logic operators, medical subject headings, and main keywords related to foodborne diarrheal disease. STATA version 17 was used to perform an analysis. The quality of the articles was evaluated using Joanna Briggs Institute appraisal tools.ResultsThe present study included 54 articles with an estimates of 103 findings. An increases in temperature, relative humidity, precipitation, rainfall, and flooding were associated with 4% [RR: 1.04; 95% CI: 1.03, 1.05], 3% [RR: 1.03; 95% CI: 1.01, 1.06], 2% [RR: 1.02; 95% CI: 1.01, 1.03], 1% [RR: 1.01; 95% CI: 1.00, 1.02], and 42% [RR: 1.42; 95% CI: 1.26, 1.57] increases in foodborne diarrhoeal disease, respectively.ConclusionThere was a significant association between foodborne diarrhoeal disease and climate variability, and indicate the need for building a climate-resilient food safety system to reduce foodborne diarrheal disease.Systematic Review Registrationidentifier CRD42024532430.