Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder: a multicentre, three-arm, randomised controlled, pilot phase-IIa trial
Copyright policy )Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder: a multicentre, three-arm, randomised controlled, pilot phase-IIa trial
Abstract Depression is common in attention-deficit/hyperactivity disorder (ADHD), but preventive behavioural interventions are lacking. This randomised controlled, pilot phase-IIa trial aimed to study a physical exercise intervention (EI) and bright light therapy (BLT)—both implemented and monitored in an individual, naturalistic setting via a mobile health (m-health) system—for feasibility of trial design and interventions, and to estimate their effects on depressive symptoms in young people with ADHD. Two hundred seven participants aged 14–45 years were randomised to 10-week add-on intervention of either BLT (10,000 lx; daily 30-min sessions) (n = 70), EI (aerobic and muscle-strengthening activities 3 days/ week) (n = 69), or treatment-as-usual (TAU) (n = 68), of whom 165 (80%) were retained (BLT: n = 54; EI: n = 52; TAU: n = 59). Intervention adherence (i.e. ≥ 80% completed sessions) was very low for both BLT (n = 13, 22%) and EI (n = 4, 7%). Usability of the m-health system to conduct interventions was limited as indicated by objective and subjective data. Safety was high and comparable between groups. Changes in depressive symptoms (assessed via observer-blind ratings, Inventory of Depressive Symptomatology) between baseline and end of intervention were small (BLT: −0.124 [95% CI: −2.219, 1.971], EI: −2.646 [95% CI: −4.777, −0.515], TAU: −1.428 [95% CI: −3.381, 0.526]) with no group differences [F(2,153) = 1.45, p = 0.2384]. These findings suggest that the m-health approach did not achieve feasibility of EI and BLT in young people with ADHD. Prior to designing efficacy studies, strategies how to achieve high intervention adherence should be specifically investigated in this patient group. Trial registration ClinicalTrials.gov, NCT03371810, 13 December 2017.
Male, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Physical Therapy Modalities::Therapeutics::Exercise Therapy, Cognitive Neuroscience - Development and lifelong plasticity, m-Health, 150, Pilot Projects, Depressió psíquica - Tractament, Comorbidity, kirkasvalohoito, Adolescents, 796, nuoret, Outcome Assessment, Health Care, Bright light therapy, Randomised controlled trial, Depression, Fototeràpia, Middle Aged, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity, satunnaistetut vertailukokeet, Exercise Therapy, Athletic & outdoor sports & games, Otros calificadores::Otros calificadores::/terapia, interventiohoito, PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression, Female, liikuntahoito, masennus, Exercici terapèutic, Adult, Adolescent, Other subheadings::Other subheadings::/therapy, 610, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Phototherapy, PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::conducta::síntomas conductuales::depresión, Young Adult, ADHD, Humans, Obesity, Exercise, info:eu-repo/classification/ddc/796, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::fototerapia, ddc:796, nuoret aikuiset, Original Paper, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::modalidades de fisioterapia::terapéutica::tratamiento por actividad física, DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adolescente, Physical exercise, Phototherapy, Attention-deficit/hyperactivity disorder, Attention Deficit Disorder with Hyperactivity, NAMED GROUPS::Persons::Age Groups::Adolescent, Trastorn per dèficit d'atenció amb hiperactivitat - Tractament
Male, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Physical Therapy Modalities::Therapeutics::Exercise Therapy, Cognitive Neuroscience - Development and lifelong plasticity, m-Health, 150, Pilot Projects, Depressió psíquica - Tractament, Comorbidity, kirkasvalohoito, Adolescents, 796, nuoret, Outcome Assessment, Health Care, Bright light therapy, Randomised controlled trial, Depression, Fototeràpia, Middle Aged, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity, satunnaistetut vertailukokeet, Exercise Therapy, Athletic & outdoor sports & games, Otros calificadores::Otros calificadores::/terapia, interventiohoito, PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression, Female, liikuntahoito, masennus, Exercici terapèutic, Adult, Adolescent, Other subheadings::Other subheadings::/therapy, 610, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Phototherapy, PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::conducta::síntomas conductuales::depresión, Young Adult, ADHD, Humans, Obesity, Exercise, info:eu-repo/classification/ddc/796, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::fototerapia, ddc:796, nuoret aikuiset, Original Paper, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::modalidades de fisioterapia::terapéutica::tratamiento por actividad física, DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adolescente, Physical exercise, Phototherapy, Attention-deficit/hyperactivity disorder, Attention Deficit Disorder with Hyperactivity, NAMED GROUPS::Persons::Age Groups::Adolescent, Trastorn per dèficit d'atenció amb hiperactivitat - Tractament
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).1 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!