Biomarkers in head and neck squamous cell carcinoma: unraveling the path to precision immunotherapy
Copyright policy )Biomarkers in head and neck squamous cell carcinoma: unraveling the path to precision immunotherapy
Recent strides in understanding the molecular underpinnings of head and neck cancers have sparked considerable interest in identifying precise biomarkers that can enhance prognostication and enable personalized treatment strategies. Immunotherapy has particularly revolutionized the therapeutic landscape for head and neck squamous cell carcinoma, offering new avenues for treatment. This review comprehensively examines the application and limitations of the established and emerging/novel biomarkers for head and neck squamous cell carcinoma. Established biomarkers, including well-characterized genetic mutations, protein expressions, and clinical factors, have been extensively studied and validated in clinical practice. Novel biomarkers identified through molecular analyses, including novel genetic alterations, immune-related markers, and molecular signatures, are currently being investigated and validated in preclinical and clinical settings. Biomarkers hold the potential to deepen our understanding of head and neck squamous cell carcinoma biology and guide therapeutic strategies. The evolving paradigm of predictive biomarkers facilitates the study of individual responses to specific treatments, including targeted therapy and immunotherapy.
- Vall d'Hebron Institute of Oncology (VHIO) Spain
- George Institute for Global Health India
- EMORY UNIVERSITY NON PROFIT CORP United States
- Emory University United States
- Seoul National University Hospital Korea (Republic of)
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia, diagnostic biomarker, CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor, ENFERMEDADES::neoplasias::neoplasias::neoplasias por localización::neoplasias de cabeza y cuello::carcinoma de células escamosas de cabeza y cuello, COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales, Marcadors tumorals, Other subheadings::Other subheadings::/therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Coll - Càncer - Immunoteràpia, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Precision Medicine, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::medicina de precisión, Otros calificadores::Otros calificadores::/terapia, DISEASES::Neoplasms::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Squamous Cell Carcinoma of Head and Neck, Oncology, squamous cell cancer, Cap - Càncer - Immunoteràpia, head and neck cancer, Medicina personalitzada, predictive biomarker, prognostic biomarker, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy, RC254-282
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia, diagnostic biomarker, CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor, ENFERMEDADES::neoplasias::neoplasias::neoplasias por localización::neoplasias de cabeza y cuello::carcinoma de células escamosas de cabeza y cuello, COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales, Marcadors tumorals, Other subheadings::Other subheadings::/therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Coll - Càncer - Immunoteràpia, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Precision Medicine, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::medicina de precisión, Otros calificadores::Otros calificadores::/terapia, DISEASES::Neoplasms::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Squamous Cell Carcinoma of Head and Neck, Oncology, squamous cell cancer, Cap - Càncer - Immunoteràpia, head and neck cancer, Medicina personalitzada, predictive biomarker, prognostic biomarker, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy, RC254-282
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