Climate change undermines forests’ health, vitality, and, as a consequence, tree functionality, productivity, and resilience to biotic disturbances. Mountain and sub-alpine forests are particularly susceptible to climate extremes and are showing signs of degradation in Europe. Warmer temperatures, drought, higher frequency and intensity of natural disturbances increasingly alter species distribution and survival, their growing capacity, reproduction, establishment, as well as their potential adaptation to climate change. Real-time monitoring of trees’ and stands’ responses to such events provides an effective way to better understand and even foresee the adverse side effects of climate change. The use of advanced and innovative monitoring tools and devices is required for ensuring long-term, large-scale, and real-time monitoring of forest dynamics. Here, we present the TreeTalker Italia Network (TTIN), i.e., the first large-scale network of tree-proximal sensors (TreeTalkers©) at a national scale in Italy. We describe the recent advances, innovations, and potential of such devices for continuous monitoring and research. As a primer, we argue that TTIN will provide effective support to ongoing science and policy efforts for monitoring natural resources’ dynamics on a large scale (e.g., forest inventory, climate impacts), including their effects on human well-being.