Abstract The paper explores the adoption of organic cotton production by smallholder farmers in Tajikistan’s northern Sughd and southwestern Khatlon regions through the lens of political ecology. The research focuses on the complex interactions among socio-economic, environmental and political variables that influence the decision-making processes of Tajikistani smallholders as they navigate the transition towards adopting organic farming practices. This transition, initiated and guided by the external actors, largely from high-income nations, emphasizes broader power dynamics and asymmetries inherent within the global agricultural system. In addition to illuminating the pivotal role of smallholder farmers in sustainable agriculture and rural development, we ask how power relations, institutional frameworks, and market dynamics impacts the adoption of organic cotton by smallholders in Tajikistan, and the implications this has for local communities. By exploring these dimensions, we emphasize the need for supportive policies and the development of inclusive market mechanisms. This study acknowledges the vulnerability of smallholders to the volatility of the global organic cotton markets, influenced by external shocks such as pandemics, wars, and natural hazards. Considering the absence of domestic markets for organic produce in Tajikistan, we stress the reliance of smallholders on turbulent external markets, highlighting the urgent need for resilient and diversified market linkages to safeguard their livelihoods.