Stabilizing the depth of the Towed Underwater Vehicle (TUV) under the impact of ocean waves is the first problem when building a control and monitoring system for TUV. Many strategies and control methods have been proposed in different studies, but they are not a general standard. Therefore, this research will propose and investigate a solution for synthesizing the control system to stabilize the TUV based on the real interpolation method (RIM) with the main contents: modeling the Towed cable (TC) - Underwater vehicle (UV) system, proposing the structure of the control system and the synthesis procedure of the regulators based on the RIM, building a synthesis program with different TC lengths. The simulation results show that the TUV exhibits good performance under the impact of sea wave. They can be applied to build the experimental models of TUV.