The main tasks of modernization of the information support system in the scientic and industrial spheres and its gradual transition to the National information system (NIS) are considered. There are highlighted the following aspects of this process: information security; promotion of the results of scientic and technical activities on the global market: participation in the formation of the global agenda in scientic and technical areas; maintaining and strengthening Russia’s position in the world as one of the leading powers and the center of competitiveness in the global information market. Attention is paid to the experience of foreign countries in the formation of national information systems. The areas of modernization cover both system-wide and technological aspects of this process. Among the main highlighted are the following: the integration of existing systems of information support in scientic and industrial spheres; accelerated formation of digital information resources and their rational placements; development of social scientic networks to increase the level of information interaction of key audiences in the segment of research, development, technology transfer; development and widespread introduction of Internet selective dissemination of information (Internet-SDI); development of the mechanism (technology) of semantic navigation and knowledge retrieval in information networks; databases system on manufactured and consumed industrial products (PPP) and standards of the Russian Federation, the countries of the international center for scientic and technical information (ICS), the BRICS countries and the countries of the Shanghai cooperation organization (SCO) creation. The macrostructure of the complex of works on modernization of the information support system in the scientic and industrial sphere is given.