The article analyzes the problem of the formation of the imperative of human activity’s explication in outer space. It is asserted that the existing international agreements and legal framework for the regulation of human activities in outer space requires thorough study and close attention from researchers. The main challenges, generated by outer space exploration, bring not only potential benefits but global threats and risks to the existence of human civilization. The enlisted problems in the outer space exploration have two levels of solutions in the legal aspect: improvement of the existing legal framework of international instruments and the design of regulation of human activity in the subsequent challenges of the interstellar world exploration. The need for legal regulation of all major manifestations of activity in outer space indicates the embryonic state of the relevant imperatives, which are closely linked to the challenges to the safety of mankind and its civilization progress. The content of the outer space exploration strategy is demonstrated from the point of non-classical paradigm of philosophy and epistemology, which significantly delegitimize modern ethical and axiological principles. The search of strategies of legal support of the civilization development in the context of space exploration is carried out according to following formulated trends: the demarcation of nationalized airspace and universal space, the problem of the militarization of the space expansion of mankind, the development of telecommunication technologies and the use of geostationary orbit, technological, medical and biological research — all these activities significantly change the direction of our daily routines and the overall security status of the earth civilization development.