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Kidney International
Article . 2024 . Peer-reviewed
License: CC BY NC ND
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Article . 2024
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Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity

Authors: Florian Grahammer; Bernhard Dumoulin; Ramila E. Gulieva; Hui Wu; Yaoxian Xu; Nurgazy Sulaimanov; Frederic Arnold; +12 Authors

Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity

Abstract

Kidney international 106(5), 856-869 (2024). doi:10.1016/j.kint.2024.08.021

Published by New York, NY, Elsevier

Countries
Germany, Netherlands, Germany
Keywords

Mice, Knockout, Polycystic Kidney Diseases, CDK4, Pyridines, bypass mechanism, 610, Cyclin-Dependent Kinase 4, Kinesins, Kidney Diseases, Cystic, Mechanistic Target of Rapamycin Complex 1, Piperazines, Mice, Disease Models, Animal, mTOR pathway, SDG 3 - Good Health and Well-being, Disease Progression, Animals, Humans, Cilia, cystic kidney disease, Protein Kinase Inhibitors, Animals; Humans; Mice; Cilia/pathology; Cilia/metabolism; Cyclin-Dependent Kinase 4/antagonists & inhibitors; Cyclin-Dependent Kinase 4/metabolism; Cyclin-Dependent Kinase 4/genetics; Disease Models, Animal; Disease Progression; Kidney Diseases, Cystic/genetics; Kidney Diseases, Cystic/metabolism; Kidney Diseases, Cystic/pathology; Kidney Diseases, Cystic/drug therapy; Kinesins/genetics; Kinesins/metabolism; Kinesins/antagonists & inhibitors; Mechanistic Target of Rapamycin Complex 1/metabolism; Mechanistic Target of Rapamycin Complex 1/antagonists & inhibitors; Mechanistic Target of Rapamycin Complex 1/genetics; Mice, Knockout; Piperazines/pharmacology; Piperazines/therapeutic use; Polycystic Kidney Diseases/genetics; Polycystic Kidney Diseases/metabolism; Polycystic Kidney Diseases/pathology; Polycystic Kidney Diseases/drug therapy; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Pyridines/pharmacology; Pyridines/therapeutic use; Signal Transduction; CDK4; bypass mechanism; cystic kidney disease; mTOR pathway, Signal Transduction

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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
hybrid