Aim. To develop and validate methods for spectrophotometric determination of meloxicam in drugs by reaction with diazole red 2G. Materials and methods. The following was used to perform the experiment: meloxicam substance pharmacopoeial purity; pharmaceutical drugs – “Meloxicam” tablets 0.0075 g, “Meloxicam” tablets 0.015 g, “Meloxicam-Teva” solution for injection 15 mg / 1.5 ml; as reagent – diazole red 2G of a reagent grade purity; solvents – 1,4-dioxane of a reagent grade purity and purified water; analytical equipment – spectrophotometer Specord-200 (Analytic Jena AG, Germany), scales laboratory electronic RADWAG XA 210.4Y, bath ultrasonic Sonorex Digitec DT100H, laboratory glassware of class A. Results. New simple spectrophotometric methods for the quantitative determination of meloxicam in pharmaceuticals by reaction with diazole red G have been developed. The absorption maximum is recorded at 350 nm. The basic law of light absorption is followed in the concentration range of 1.2–2.4 mg / 100 ml. The limit of detection is 1.09 μg/ml, indicating a high sensitivity of the reaction. Linearity, limit of detection, limit of quantification, range of application, precision, accuracy and robustness were determined according to the requirements of the State Pharmacopoeia of Ukraine. Conclusions. As a result of the study, spectrophotometric methods for the quantitative determination of meloxicam in medicinal products were developed and validated. The methods are simple, affordable and comply with the requirements of the State Pharmacopoeia of Ukraine, so they can be recommended for use in drug quality control laboratories.