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Beilstein Journal of Organic Chemistry
Article . 2025 . Peer-reviewed
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PubMed Central
Other literature type . 2025
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Beilstein Journal of Organic Chemistry
Article . 2025
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High-pressure activation for the solvent- and catalyst-free syntheses of heterocycles, pharmaceuticals and esters

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 02 Jul 2025 English Publisher:Beilstein InstitutJournal:Beilstein Journal of Organic Chemistry, volume 21, pages 1,374-1,387 (eissn: 1860-5397, Copyright policy )Funded by:NIH | Green Synthesis of Buildi...
Authors: Kelsey Plasse; Valerie Wright; Guoshu Xie; R Bernadett Vlocskó; Alexander Lazarev; Béla Török;

doi: 10.3762/bjoc.21.102

High-pressure activation for the solvent- and catalyst-free syntheses of heterocycles, pharmaceuticals and esters

Abstract

High hydrostatic pressure (HHP) was found to be an efficient activation method in several catalyst- and solvent-free reactions and has found application for the syntheses of heterocycles and the preparation of active pharmaceutical ingredients (APIs) via acylation and acid- and solvent-free esterification. The reactions were carried out at ambient pressure (control) and under HHP (up to 3.8 kbar) conditions. These representative reactions provided higher yields for the products and HHP enabled truly green processes that are catalyst- and solvent-free, to occur with high yields and producing only non-toxic by-products. A computational study accompanies the experimental data to interpret the outcome of the reactions.

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Keywords

benzimidazoles, catalyst-free synthesis, cyclization, esters, QD241-441, high hydrostatic pressure, Science, Q, Organic chemistry, acetylsalicylic acid, pyrazoles, Full Research Paper, acetaminophen

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
Published in a Diamond OA journal