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European Journal of Clinical Pharmacology
Article . 2020 . Peer-reviewed
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Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany

Authors: Thi Ngoc Mai Nguyen; Dana Clarissa Laetsch; Li-Ju Chen; Walter Emil Haefeli; Andreas D Meid; Hermann Brenner; Ben Schöttker;

Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany

Abstract

Abstract Purpose Chronic pain is common in the older population and a significant public health concern. However, comprehensive studies on analgesics use in this age group from Germany are scarce. This study aims to give a comprehensive overview on the use of the most common therapeutic groups of analgesics in community-dwelling older adults from Germany. Methods A cross-sectional study was carried out using data from a German cohort of 2038 community-dwelling adults aged 63–89 years. Descriptive statistics and logistic regression models were applied to assess the utilization of analgesics by age, sex, pain severity, pain duration, and locations. Results One out of four study participants was suffering from high-intensity or disabling pain. Approximately half of those taking analgesics still reported to suffer from high-intensity or disabling pain. Among analgesics users, occasional non-steroidal anti-inflammatory drugs (NSAIDs) use was the most frequent pain therapy (in 43.6% of users), followed by metamizole (dipyrone) use (16.1%), regular NSAIDs use (12.9%), strong opioids use (12.7%), and weak opioids use (12.0%). In multivariate logistic regression models, higher age, higher pain severity, longer pain duration, abdominal pain, and back pain were statistically significantly associated with opioids use. Metamizole use was also statistically significantly associated with higher pain severity but inversely associated with pain duration. Conclusions A significant number of older German adults are affected by high-intensity and disabling chronic pain despite receiving analgesics. Long-term studies are needed to compare the effectiveness and safety of different treatments for chronic pain in older adults.

Keywords

Aged, 80 and over, Male, Aged, 80 and over [MeSH] ; Aged [MeSH] ; Surveys and Questionnaires/statistics ; Analgesics ; Germany/epidemiology [MeSH] ; Dipyrone/therapeutic use [MeSH] ; Analgesics, Opioid/therapeutic use [MeSH] ; Chronic Pain/diagnosis [MeSH] ; Chronic Pain/epidemiology [MeSH] ; Male [MeSH] ; Drug Utilization/statistics ; Independent Living/statistics ; Prevalence [MeSH] ; Female [MeSH] ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use [MeSH] ; Follow-Up Studies [MeSH] ; Older adult ; Humans [MeSH] ; Severity of Illness Index [MeSH] ; Treatment Outcome [MeSH] ; Drug utilization study ; NSAIDs ; Chronic Pain/drug therapy [MeSH] ; Opioids ; Middle Aged [MeSH] ; Cross-Sectional Studies [MeSH] ; Pain Measurement/statistics ; Metamizole ; Pharmacoepidemiology and Prescription, Pharmacoepidemiology and Prescription, Anti-Inflammatory Agents, Non-Steroidal, Dipyrone, Middle Aged, Severity of Illness Index, Drug Utilization, Analgesics, Opioid, Cross-Sectional Studies, Treatment Outcome, Germany, Surveys and Questionnaires, Prevalence, Humans, Female, Independent Living, Chronic Pain, Aged, Follow-Up Studies, Pain Measurement

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    popularity
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    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Top 10%
Average
Average
Green
hybrid