Inverse relation between levels of anti-oxidized-LDL antibodies and eicosapentanoic acid (EPA)
Copyright policy )Inverse relation between levels of anti-oxidized-LDL antibodies and eicosapentanoic acid (EPA)
Oxidative modification of LDL is thought to play an important role in the development of atherosclerosis. Susceptibility of LDL to peroxidation may partly depend on the compositional characteristics of the antioxidant and fatty acid content. The aim of this study was to examine the association between levels of antibodies to oxidized LDL and the various serum fatty acids in women. A total of 465 women aged 18–65 years were selected randomly from the adult population census of Pizarra, a town in southern Spain. Measurement of anti-oxidized-LDL was done by ELISA and the fatty acid composition of serum phospholipids was determined by GC. The levels of anti-oxidized-LDL antibodies were significantly related with age (r − 0·341, P < 0·001), BMI (r − 0·239, P < 0·001), waist:hip ratio (r − 0·285, P < 0·001), glucose (r − 0·208, P < 0·001), cholesterol (r − 0·243, P < 0·001), LDL-cholesterol (r − 0·185, P = 0·002), EPA (r − 0·159, P = 0·003), DHA (r − 0·121, P = 0·026), and the sum of the serum phospholipid n-3 PUFA (r − 0·141, P = 0·009). Multiple regression analysis showed that the variables that explained the behaviour of the levels of anti-oxidized-LDL antibodies were age (P < 0·001) and the serum phospholipid EPA (P < 0·001). This study showed that the fatty acid composition of serum phospholipids, and especially the percentage of EPA, was inversely related with the levels of anti-oxidized-LDL antibodies.
Oxidized LDL, Adult, Medical Subject Headings::Chemicals and Drugs::Lipids::Fats::Dietary Fats::Dietary Fats, Unsaturated::Fatty Acids, Omega-3::Eicosapentaenoic Acid, Anticuerpos, Adolescent, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies, Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged, Ácido Eicosapentaenoico, Antibodies, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Young Adult, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult, Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL, Fosfolípidos, Humans, Ácidos Grasos, Fatty acids, Medical Subject Headings::Named Groups::Persons::Age Groups::Adolescent, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged, Phospholipids, Aterosclerosis, Aged, Autoantibodies, Análisis de Regresión, Fatty Acids, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis, Ácidos Grasos Insaturados, Lipoproteínas LDL, Age Factors, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young Adult, Medical Subject Headings::Check Tags::Female, Autoanticuerpos, Middle Aged, Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Age Factors, Lipoproteins, LDL, Factores de edad, Eicosapentaenoic Acid, Medical Subject Headings::Chemicals and Drugs::Lipids::Phospholipids, Fatty Acids, Unsaturated, Regression Analysis, Female, Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids
Oxidized LDL, Adult, Medical Subject Headings::Chemicals and Drugs::Lipids::Fats::Dietary Fats::Dietary Fats, Unsaturated::Fatty Acids, Omega-3::Eicosapentaenoic Acid, Anticuerpos, Adolescent, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies, Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged, Ácido Eicosapentaenoico, Antibodies, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Young Adult, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult, Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL, Fosfolípidos, Humans, Ácidos Grasos, Fatty acids, Medical Subject Headings::Named Groups::Persons::Age Groups::Adolescent, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged, Phospholipids, Aterosclerosis, Aged, Autoantibodies, Análisis de Regresión, Fatty Acids, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis, Ácidos Grasos Insaturados, Lipoproteínas LDL, Age Factors, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young Adult, Medical Subject Headings::Check Tags::Female, Autoanticuerpos, Middle Aged, Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Age Factors, Lipoproteins, LDL, Factores de edad, Eicosapentaenoic Acid, Medical Subject Headings::Chemicals and Drugs::Lipids::Phospholipids, Fatty Acids, Unsaturated, Regression Analysis, Female, Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids
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