Due to high-dimensional feature and strong correlation of features, the classification accuracy of medical data is not as good enough as expected. feature selection is a common algorithm to solve this problem, and selects effective features by reducing the dimensionality of high-dimensional data. However, traditional feature selection algorithms have the blindness of threshold setting and the search algorithms are liable to fall into a local optimal solution. Based on it, this paper proposes a hybrid feature selection algorithm combining ReliefF and Particle swarm optimization. The algorithm is mainly divided into three parts: Firstly, the ReliefF is used to calculate the feature weight, and the features are ranked by the weight. Then ranking feature is grouped according to the density equalization, where the density of features in each group is the same. Finally, the Particle Swarm Optimization algorithm is used to search the ranking feature groups, and the feature selection is performed according to a new fitness function. Experimental results show that the random forest has the highest classification accuracy on the features selected. More importantly, it has the least number of features. In addition, experimental results on 2 medical datasets show that the average accuracy of random forest reaches 90.20%, which proves that the hybrid algorithm has a certain application value.