Wound healing which is a usual biological process in our body is attained by four accurate and highly organized stages: hemostasis, inflammation, proliferation, and remodeling. In order to achieve a proper and successful wound healing, all these stages must occur in an appropriate sequence under a certain period of time. Many factors can disturb one or more stage of this process, hence resulting an inappropriate or ruined wound healing.Aim of research. This article investigates the influence of nanoceria on C-reactive protein and Middle-mass molecules concentration in blood serum of rats after full-thickness wound model.Materials and Methods. These two factors are considered to be indicators for endogenous intoxication, thus controlling their level in blood serum plays a key role in the wound healing process. The experimental procedure was conducted by the Gabrielyan method for Middle-mass molecules (MMM) concentration measurement and turbidimetry for C-reactive protein.Result. It was shown the elevated level of MMM in blood serum in the control group of rats. In contrast, where the treatment of wounds was carried out by Nanoceria in experimental group, the level of MMM decreased significantly in each day of experiment till 20th day when the full re-epithelialization occurred. And we demonstrated an increase in the level of CRP on the 3rd, 6th, 9th and 14th days of the experiment in comparison with the control in blood serum of all the experimental groups. Restoration of this indicator to normal values was observed in the groups of animals that received Nanoceria on the 20th day of the experiment, it correlated with full re-epithelialization.Conclusion. Due to several other advantages of Nanoceria, such as balancing some growth factors, Antioxidant, Antimicrobial, ROS reduction, SOD restoration, Catalase reduction properties that were investigated and proved in our previous studies, we consider Nanoceria as a promising drug for further investigation