Thin films for the SiO2–P2O5–CaO–ZnO system were synthesized by the sol-gel method. The compositions and technology for producing thin-film materials on a silicon substrate (model substrate) were developed. The structure of the films was investigated by means of infrared spectroscopy and x-ray phase analysis. It was established that the concentration and contents of the components in the system influence the properties of thin-film materials. The obtained materials are biologically highly active. The composition for obtaining thin-film material with a higher biological activity was determined.