Cyber-Physical Systems (CPSs) are integrations of distributed computing systems with physical processes via a networking with actuators and sensors, where feedback loops among the components allow the physical processes to affect the computations and vice versa. Although CPSs can be found in several complex and sometimes critical real-world domains, their verification and validation often relies on simulation-test systems rather then automatic methodologies to formally verify safety requirements. In this work, we prove the decidability of the reachability problem for discrete-time linear CPSs whose physical process in isolation has a periodic behavior, up to an initial transitory phase.