Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children
Copyright policy )Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children
Acute pyelonephritis is associated with considerable morbidity and potential for renal scarring. Pentraxin3 (PTX3) is a recently discovered mediator of inflammation. The objective of this study was to investigate the changes in serum and urine PTX3 levels in children who had a history of pyelonephritis and were diagnosed with renal parenchymal scar (RPS) and/or vesicoureteral reflux (VUR).The study included 88 children (31 males, 57 females) aged between 3 months and 18 years. The children included in the study were divided into four groups: VUR with RPS (Group 1), RPS without VUR (Group 2), VUR without RPS (Group 3), and healthy children without a history of hydronephrosis or UTI history (Group 4). After the initial evaluation, the participants were further divided into two more groups and re-evaluated: Children with RPS (Group 1 + 2), children without RPS (Group 3 + 4), children with VUR (Group 1 + 3), and children without VUR (Group 2 + 4).We found that urine pentraxin 3 (uPTX3) and uPTX3/Creatinine levels were significantly higher in the groups with renal scar with or without VUR than the ones without RPS [mean uPTX3, 3.5 pg/ml (min-max 0.0022-12.3668) vs. 2.2 pg/ml (min-max 0.0022-18.5868) and uPTX3/creatinine, 10.5 pg/mg (min-max 0.0035-51.1) vs. 5.8 pg/mg (min-max 0.0004-78.7), p < 0.01]. uPTX3 levels were not different among the groups with and without VUR. In addition, serum PTX3 levels were not different among the groups.We showed that urinary PTX3 increased only in patients with scarred kidneys. These results might be helpful to predict RPS due to past pyelonephritis.
- Çanakkale Onsekiz Mart University Turkey
- Pamukkale University Turkey
- Namık Kemal University Turkey
Male, clinical evaluation, acute pyelonephritis, Pentraxin 3, preschool child, kidney parenchyma, pentraxin 3, Child, Children, acute disease, child, C reactive protein, Pyelonephritis, adult, Vesicoureteral reflux, creatinine, correlational study, biological marker, kidney scar, medical history, urine, Serum Amyloid P-Component, female, C-Reactive Protein, Child, Preschool, Creatinine, Acute Disease, pyelonephritis, Female, Adolescent, Renal scar, 610, urinary excretion, complication, protein urine level, scar, Article, 618, Cicatrix, male, Acute Disease; Adolescent; Biomarkers/blood/urine; C-Reactive Protein/metabolism/*urine; Case-Control Studies; Child; Child, Preschool; Cicatrix/etiology/*urine; Creatinine/urine; Female; Humans; Infant; Male; Pyelonephritis/*complications; Serum Amyloid P-Component/metabolism/*urine; Vesico-Ureteral Reflux/complications/*urine, blood, serum amyloid P, Humans, human, Preschool, Vesico-Ureteral Reflux, disease association, Infant, vesicoureteral reflux, case control study, infant, major clinical study, adolescent, Case-Control Studies, metabolism, Biomarkers
Male, clinical evaluation, acute pyelonephritis, Pentraxin 3, preschool child, kidney parenchyma, pentraxin 3, Child, Children, acute disease, child, C reactive protein, Pyelonephritis, adult, Vesicoureteral reflux, creatinine, correlational study, biological marker, kidney scar, medical history, urine, Serum Amyloid P-Component, female, C-Reactive Protein, Child, Preschool, Creatinine, Acute Disease, pyelonephritis, Female, Adolescent, Renal scar, 610, urinary excretion, complication, protein urine level, scar, Article, 618, Cicatrix, male, Acute Disease; Adolescent; Biomarkers/blood/urine; C-Reactive Protein/metabolism/*urine; Case-Control Studies; Child; Child, Preschool; Cicatrix/etiology/*urine; Creatinine/urine; Female; Humans; Infant; Male; Pyelonephritis/*complications; Serum Amyloid P-Component/metabolism/*urine; Vesico-Ureteral Reflux/complications/*urine, blood, serum amyloid P, Humans, human, Preschool, Vesico-Ureteral Reflux, disease association, Infant, vesicoureteral reflux, case control study, infant, major clinical study, adolescent, Case-Control Studies, metabolism, Biomarkers
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