Purpose. Determination of the stress-strain state of a typical continuous steel truss span by calculation according to national norms and computer simulation in the conditions of passage of high-speed passenger trains. Methodology. In this work, the stress-strain state of a continuous truss span of the typical project No. 3 501.2-166 for the possibility of its application in areas with perspective high-speed railway traffic was investigated. Calculation of the specified span structure for DBN V.2.3-14-2006 «Constructions of transport. Bridges and pipes. Design rules» for railroad loading С14 was executed. The cross-sections of the elements of a continuous truss span were calculated and the necessary checks performed. For the given span structure in the software complex a model was developed and the stress-strain state at various speeds of railway transport according to European and national norms was investigated. The acceleration and deflection of a continuous steel truss span were determined and their comparison with normative requirements was performed. Findings. As a result of simulation in the software complex for a continuous steel truss span, acceleration and deflection under the action of cargo and passenger load at different speeds of movement were determined. The cross-sections of the elements of a continuous steel truss span were calculated. Originality. The results of the study can be applied in the development of national regulatory documents on high-speed rail transport and in the design of bridge structures with continuous truss spans in areas with high and higher-speed railway traffic. Practical value. The obtained results of the research will allow to effectively use continuous steel truss spans of typical designs in areas with high– and higher-speed railway traffic.