Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao IRIS Cnrarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Neural Computing and Applications
Article . 2025 . Peer-reviewed
License: Springer Nature TDM
Data sources: Crossref
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
versions View all 3 versions
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

Toward trustworthy and sustainable clinical decision support by training ensembles of specialized logistic regressors

Authors: Cuzzocrea, Alfredo; Folino, Francesco; Pontieri, Luigi; Sabatino, Pietro; Samami, Maryam;

Toward trustworthy and sustainable clinical decision support by training ensembles of specialized logistic regressors

Abstract

This paper presents a novel Mixture of Experts (MoE)-based framework designed to enhance clinical decision-making by balancing predictive accuracy, interpretability, and adaptability. Our approach relies on a set of locally specialized logistic regression models, dynamically selecting the most suitable expert for each instance based on local feature patterns. To enforce sparsity in both the gating mechanism and expert models, we employ the Gumbel-softmax relaxation, enabling end-to-end differentiable selection of both the active expert and the most relevant features for each prediction. By integrating this mechanism, our method improves computational efficiency and generalization while maintaining instance-level interpretability. Unlike black-box models that require post hoc explanation techniques, our solution provides transparency by construction, offering direct insights into feature contributions for each decision. We evaluated our approach on multiple real-world healthcare datasets, spanning both standard clinical classification tasks and process-oriented predictive scenarios. Experimental results demonstrated that our MoE-based framework achieves robust and competitive performance while maintaining lower complexity than black-box methods such as XGBoost and Random Forest and improving generalization over simpler interpretable models, including Decision Trees, Linear Trees, and standard Logistic Regressors. Additionally, our analysis of the trade-off between model complexity and predictive performance shows that our method delivers stable and reliable results across diverse datasets and evaluation metrics. These findings underscore the advantages of an interpretable MoE-based approach in clinical AI, supporting transparent and accountable decision-making.

Keywords

XAI, Clinical DSSs, Machine learning, Green AI, Outcome prediction

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    2
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Top 10%
Average
Average
Upload OA version
Are you the author of this publication? Upload your Open Access version to Zenodo!
It’s fast and easy, just two clicks!