Spinal cord involvement in progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome
Copyright policy )Spinal cord involvement in progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infectious demyelinating disease of the central nervous system caused by JC polyomavirus predominantly affecting immunocompromised individuals. Nowadays, HIV, hematological malignancies and iatrogenic immune suppression account for most PML cases. For unknown reasons, spinal cord is classically protected from PML lesions. Here, we report the course of a patient harboring spinal cord lesions in the context of PML with immune reconstitution inflammatory syndrome and review the eight other cases reported in the literature so far. Then, we discuss the evolving spectrum of PML over recent years, potentially making its diagnosis more challenging.
- University of Liège Belgium
- Centre Hospitalier Universitaire de Liège Belgium
Male, Leukoencephalopathy, Progressive Multifocal/immunology, Immune Reconstitution Inflammatory Syndrome/pathology, HIV Infections/drug therapy, HIV Infections/complications, HIV Infections, JC Virus/immunology, Leukoencephalopathy, Progressive Multifocal/virology, JC virus, Spinal Cord/pathology, Sciences de la santé humaine, Immunologie & maladie infectieuse, Maraviroc, Immune Reconstitution Inflammatory Syndrome/virology, HIV Infections/immunology, Cellular and Molecular Neuroscience, Spinal Cord/diagnostic imaging, Immune Reconstitution Inflammatory Syndrome/drug therapy, JC Virus/pathogenicity, Immune Reconstitution Inflammatory Syndrome, Virology, Neurologie, Humans, Immunology & infectious disease, Leukoencephalopathy, Progressive Multifocal/pathology, Human health sciences, Spinal cord lesions, PML, Leukoencephalopathy, Progressive Multifocal, IRIS, Middle Aged, JC Virus, Magnetic Resonance Imaging, Leukoencephalopathy, Progressive Multifocal/drug therapy, Immune Reconstitution Inflammatory Syndrome/immunology, Neurology, Spinal Cord, Spinal Cord/virology, Spinal Cord/immunology, HIV Infections/virology, Neurology (clinical)
Male, Leukoencephalopathy, Progressive Multifocal/immunology, Immune Reconstitution Inflammatory Syndrome/pathology, HIV Infections/drug therapy, HIV Infections/complications, HIV Infections, JC Virus/immunology, Leukoencephalopathy, Progressive Multifocal/virology, JC virus, Spinal Cord/pathology, Sciences de la santé humaine, Immunologie & maladie infectieuse, Maraviroc, Immune Reconstitution Inflammatory Syndrome/virology, HIV Infections/immunology, Cellular and Molecular Neuroscience, Spinal Cord/diagnostic imaging, Immune Reconstitution Inflammatory Syndrome/drug therapy, JC Virus/pathogenicity, Immune Reconstitution Inflammatory Syndrome, Virology, Neurologie, Humans, Immunology & infectious disease, Leukoencephalopathy, Progressive Multifocal/pathology, Human health sciences, Spinal cord lesions, PML, Leukoencephalopathy, Progressive Multifocal, IRIS, Middle Aged, JC Virus, Magnetic Resonance Imaging, Leukoencephalopathy, Progressive Multifocal/drug therapy, Immune Reconstitution Inflammatory Syndrome/immunology, Neurology, Spinal Cord, Spinal Cord/virology, Spinal Cord/immunology, HIV Infections/virology, Neurology (clinical)
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