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Rheumatology
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Capi-score: a quantitative algorithm for identifying disease patterns in nailfold videocapillaroscopy

Authors: Borja del Carmelo Gracia Tello; Luis Sáez Comet; Gema Lledó; Mayka Freire Dapena; Miguel Antonio Mesa; Miguel Martín-Cascón; Alfredo Guillén del Castillo; +9 Authors

Capi-score: a quantitative algorithm for identifying disease patterns in nailfold videocapillaroscopy

Abstract

Abstract Objectives EULAR supports the use of nailfold videocapillaroscopy (NVC) for identifying disease patterns (DPs) associated with SSc and RP. Recently, EULAR proposed an easy-to-manage procedure, a so-called Fast Track algorithm, for differentiating SSc patterns from non-SSc patterns in NVC specimens. However, subjectivity among capillaroscopists remains a limitation. Our aim was to perform a software-based analysis of NVC peculiarities in a cohort of samples from SSc and RP patients and, subsequently, build a Fast Track–inspired algorithm for identifying DPs without the constraint of interobserver variability. Methods NVCs were examined by 9 capillaroscopists. Those NVCs whose DPs were consensually agreed upon (by ≥2 out of 3 interobservers) were subsequently analysed using in-house–developed software. The results for each variable were grouped according to the consensually agreed-upon DPs in order to identify useful hallmarks for categorizing them. Results A total of 851 NVCs (21 957 images) whose DPs had been consensually agreed upon were software-analysed. Appropriate cut-offs set for capillary density and percentage of abnormal and giant capillaries, tortuosities and haemorrhages allowed DP categorization and the development of the CAPI-score algorithm. This consisted of four rules: Rule 1, SSc vs non-SSc, accuracy 0.88; Rules 2 and 3, SSc-early vs SSc-active vs SSc-late, accuracy 0.82; Rule 4, non-SSc normal vs non-SSc non-specific, accuracy 0.73. Accuracy improved when the analysis was limited to NVCs whose DPs had achieved full consensus between the interobservers. Conclusion The CAPI-score algorithm may become a tool that is useful in assigning DPs by overcoming the limitations of subjectivity.

Keywords

Male, Adult, Programari, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::microscopía::microscopía intravital::angioscopia microscópica, Raynaud's Phenomenon, Video Recording, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Microscopy::Intravital Microscopy::Microscopic Angioscopy, Esclerosi sistemàtica progressiva - Imatgeria, Microscopic Angioscopy, CIENCIA DE LA INFORMACIÓN::Ciencias de la información::metodologías computacionales::soporte lógico (informática), ANATOMÍA::integumento común::uñas, 616, DISEASES::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma, Systemic, Humans, Capil·laroscòpia, Aged, ANATOMÍA::sistema cardiovascular::vasos sanguíneos::microvasos::capilares, Observer Variation, Scleroderma, Systemic, Nailfold videocapillaroscopy, Capil·lars, Fast Track algorithm, Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen, Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging, INFORMATION SCIENCE::Information Science::Computing Methodologies::Software, Clinical Science, Middle Aged, Capillaries, ANATOMY::Cardiovascular System::Blood Vessels::Microvessels::Capillaries, Software-based algorithm, Nails, Ungles, ANATOMY::Integumentary System::Nails, Systemic sclerosis, Female, ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémica, Algorithms, Software, Quantitative

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
8
Top 10%
Average
Top 10%
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