Hepatitis From Spiroplasma sp. in an Immunocompromised Patient
Copyright policy )Hepatitis From Spiroplasma sp. in an Immunocompromised Patient
A 70-year-old lung transplant recipient patient was admitted with fever, nausea, abdominal pain, peripheral edema and pronounced weakness. An initial work-up for presumed infection revealed cholestatic hepatitis, leukocytosis and thrombocytopenia, but failed to detect a pathogen. An increased glucose uptake exclusively in the liver was demonstrated by positron emission tomography. Liver biopsy showed basophilic inclusions in the cytoplasm of hepatocytes. Broad- range 16S rRNA gene PCR followed by sequence analysis yielded Spiroplasma sp. in two independent blood samples and the liver biopsy, confirming Spiroplasma sp. as the causative agent. Antibiotic treatment with doxycycline and azithromycin led to complete recovery.
- University Hospital of Zurich Switzerland
- University of Zurich Switzerland
DNA, Bacterial, 2747 Transplantation, Spiroplasma, 610 Medicine & health, Polymerase Chain Reaction, Hepatitis, 10234 Clinic for Infectious Diseases, Immunocompromised Host, 10049 Institute of Pathology and Molecular Pathology, RNA, Ribosomal, 16S, 2736 Pharmacology (medical), Humans, Radionuclide Imaging, Aged, 10179 Institute of Medical Microbiology, Prognosis, Anti-Bacterial Agents, 2723 Immunology and Allergy, 570 Life sciences; biology, Female, 10178 Clinic for Pneumology, Gram-Negative Bacterial Infections, Lung Diseases, Interstitial, Lung Transplantation
DNA, Bacterial, 2747 Transplantation, Spiroplasma, 610 Medicine & health, Polymerase Chain Reaction, Hepatitis, 10234 Clinic for Infectious Diseases, Immunocompromised Host, 10049 Institute of Pathology and Molecular Pathology, RNA, Ribosomal, 16S, 2736 Pharmacology (medical), Humans, Radionuclide Imaging, Aged, 10179 Institute of Medical Microbiology, Prognosis, Anti-Bacterial Agents, 2723 Immunology and Allergy, 570 Life sciences; biology, Female, 10178 Clinic for Pneumology, Gram-Negative Bacterial Infections, Lung Diseases, Interstitial, Lung Transplantation
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).11 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!