Acute and chronic diseases of the upper respiratory tract account for a significant proportion of diseases both in adults and children. For example, in the United States, sinusitis is now the most widespread disease the incidence of which is higher than that of hypertension and arthritis (according to the National Center for Health Statistics, USA). At the same time, inefficacy of local and systemic antimicrobial and antiviral therapies due to polyvalent resistance and absence of new formulas in the market is becoming a pressing issue. Physical therapy and surgical techniques do not always lead to a desired outcome. A review of causes of failed effectiveness of ENT treatments supports the fact immunological reactivity of the patients has changed