The work focuses on unfavorable factors with well-grounded features that influence the development of postoperative complications of transurethral resection of the prostate (TURP). 266 patients with benign prostatic hyperplasia (BPH) were analyzed, including 141 cases in urgent and 125 planned procedures, which had undergone TURP in the Urological departments of the Oleksandrivka Clinical Hospital in Kyiv in 2015–2016. There was determined informative value (in points) of each sign (27, included in 13 factors), as well as the significance of relative risk. Based on their analytical and synthetic analysis, the prognostic cards for outpatient-polyclinic and in-patient stages of providing medical care to contingents are compiled. The principle of distribution of patients with BPH is proposed for two groups of risk (minimum and maximum). Thus, for clinical urology, a convenient, cost-effective tool for taking appropriate action at certain stages of medical care and choosing the optimal timing for surgical treatment is offered. The essence of the unified approach is in summarizing the existing features in the patient at the time of the survey, the magnitude of which correlates with the objectified limit values for each group, while an algorithm of action is presented.