Biomarkers of GH action in children and adults

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2018 English Publisher:Elsevier BVJournal:Growth Hormone & IGF Research, volume 40, pages 1-8 (issn: 1096-6374,

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Authors: Schilbach, Katharina; Olsson, Daniel S; Boguszewski, Margaret C S; Bidlingmaier, Martin; Johannsson, Gudmundur; Jørgensen, Jens-Otto Lunde;

doi: 10.1016/j.ghir.2018.03.005

pmid: 29601998

Biomarkers of GH action in children and adults

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Abstract

Growth hormone (GH) and IGF-I levels in serum are used as biomarkers in the diagnosis and management of GH-related disorders but have not been subject to structured validation. Auxological parameters in children and changes in body composition in adults, as well as metabolic parameters and patient related outcomes are used as clinical and surrogate endpoints. New treatment options, such as long acting GH and GH antagonists, require reevaluation of the currently used biochemical biomarkers. This article will review biomarkers, surrogate endpoints and clinical endpoints related to GH treatment in children and adults as well as in acromegaly.

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Keywords

Adult, Hormone Replacement Therapy, Human Growth Hormone, Human Growth Hormone/therapeutic use, Outcome Assessment (Health Care)/methods, Biomarkers/analysis, Outcome Assessment, Health Care, Humans, Growth Disorders/drug therapy, Child, Biomarkers, Growth Disorders

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