Anthropogenic activities such as artisanal mining pose a major environmental health concern due to the potential for discharge of toxic metals into the environment.To determine the distribution and pollution patterns of arsenic (As), iron (Fe), nickel (Ni), cobalt (Co), chromium (Cr), manganese (Mn), copper (Cu) and zinc (Zn) in the topsoil of a mining community in Ghana, along with potential human health risks and in vitro bioaccessibility.Concentrations of metals were determined using X-ray fluorescence techniques and validated using inductively coupled plasma-mass spectrometry.Concentrations of the metals in topsoil were in the order of magnitude of Cu (31.38 mg/kg) Cu (29± 2.6%) > Ni (22± 1.3%) > As (9± 0.5%) > Cr (4± 0.6%) > Fe (2± 0.4%).Incorporation of in-vitro bioaccessibility into the risk characterization models resulted in a hazard index of less than 1, implying low human health risks. However, due to accumulation effects of the metals, regular monitoring is required.The authors declare no competing financial interests.