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Fast and efficient joint modelling of multivariate longitudinal data and time-to-event data with a pairwise-fitting approach

Authors: De Witte, Dries; Molenberghs, Geert; Abad, Ariel Alonso; Neyens, Thomas; Verbeke, Geert;

Fast and efficient joint modelling of multivariate longitudinal data and time-to-event data with a pairwise-fitting approach

Abstract

In empirical studies, multiple outcomes are often measured repeatedly over time, and interest frequently lies in studying the association between these longitudinal outcomes and a time-to-event outcome. Therefore, shared-parameter joint models for longitudinal and time-to-event outcomes have been developed. However, while such joint models in theory also allow for multiple longitudinal outcomes, they are often restricted to a limited number of outcomes due to computational complexity when fitting the models. To address this problem, we propose a new joint model, which is based on correlated instead of shared random effects, and for which a pairwise-modelling strategy can be used. In this approach, the longitudinal outcomes are modelled with (generalized) linear mixed models and the survival outcome with a Weibull proportional hazards frailty model. Instead of fitting the full joint model, this approach involves fitting all possible bivariate models, and inference is based on pseudo-likelihood theory. The main advantage of our approach is that there is no restriction on the number of longitudinally measured outcomes that are jointly modelled with the time-to-event outcome.

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Keywords

Science & Technology, Statistics & Probability, MIXED MODELS, 0104 Statistics, TRANSFORMATION, linear mixed models, LIKELIHOOD, survival data, 4905 Statistics, high-dimensional data, 3802 Econometrics, pseudo-likelihood, Physical Sciences, SURVIVAL, 1403 Econometrics, Mathematics, weibull proportional hazards frailty model

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green