Long non-coding RNA PRKG1-AS1 Promotes Cell Proliferation and Migration in Lung Adenocarcinoma
Copyright policy )Long non-coding RNA PRKG1-AS1 Promotes Cell Proliferation and Migration in Lung Adenocarcinoma
Abstract In previous studies, we have discovered a significant correlation between cGMP-dependent protein kinase I antisense RNA 1 (PRKG1-AS1) and the prognosis of lung adenocarcinoma (LUAD). Through analysis of The Cancer Genome Atlas (TCGA) database and expression data from non-small cell lung cancer tissues and cells, we found that PRKG1-AS1 is overexpressed in LUAD tissues. High expression of PRKG1-AS1 is associated with poor prognosis in LUAD patients. Cox regression analysis revealed that PRKG1-AS1 is an independent factor affecting the prognosis of LUAD. Gene Set Enrichment Analysis (GSEA) results indicated that PRKG1-AS1 might participate in various cancer-related biological processes and signaling pathways, including immune response. Furthermore, our study demonstrated that knockdown of PRKG1-AS1 expression inhibited proliferation and metastasis in LUAD. Correlation analysis between PRKG1-AS1 and protein-coding genes (PCGs) revealed a positive correlation between PRKG1-AS1 and dickkopf-1 (DKK1). Downregulation of PRKG1-AS1 led to decreased expression of DKK1, which is highly expressed in LUAD and is associated with poor prognosis. In summary, our findings suggest that PRKG1-AS1 may function as an oncogene contributing to the development of LUAD and holds significant prognostic value.
- Second Affiliated Hospital of Xi'an Jiaotong University China (People's Republic of)
LUAD, Male, Lung Neoplasms, RC705-779, DKK1, PRKG1-AS1, Research, Proliferation, Adenocarcinoma of Lung, Middle Aged, Metastasis, Gene Expression Regulation, Neoplastic, Diseases of the respiratory system, Cell Movement, A549 Cells, Humans, Animals, Intercellular Signaling Peptides and Proteins, RNA, Long Noncoding, Female, Cell Proliferation
LUAD, Male, Lung Neoplasms, RC705-779, DKK1, PRKG1-AS1, Research, Proliferation, Adenocarcinoma of Lung, Middle Aged, Metastasis, Gene Expression Regulation, Neoplastic, Diseases of the respiratory system, Cell Movement, A549 Cells, Humans, Animals, Intercellular Signaling Peptides and Proteins, RNA, Long Noncoding, Female, Cell Proliferation
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