Autonomous vehicles with a self-evolving ability are expected to cope with unknown scenarios in the real-world environment. Take advantage of trial and error mechanism, reinforcement learning is able to self evolve by learning the optimal policy, and it is particularly well suitable for solving decision-making problems. However, reinforcement learning suffers from safety issues and low learning efficiency, especially in the continuous action space. Therefore, the motivation of this paper is to address the above problem by proposing a hybrid Mechanism-Experience-Learning augmented approach. Specifically, to realize the efficient self-evolution, the driving tendency by analogy with human driving experience is proposed to reduce the search space of the autonomous driving problem, while the constrained optimization problem based on a mechanistic model is designed to ensure safety during the self-evolving process. Experimental results show that the proposed method is capable of generating safe and reasonable actions in various complex scenarios, improving the performance of the autonomous driving system. Compared to conventional reinforcement learning, the safety and efficiency of the proposed algorithm are greatly improved. The training process is collision-free, and the training time is equivalent to less than 10 minutes in the real world.