Downloads provided by UsageCountsInvestigation of gene–environment interactions in relation to tic severity
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Mohamed Abdulkadir; Dongmei Yu; Lisa Osiecki; Robert A. King; Thomas V. Fernandez; Lawrence W. Brown; Keun-Ah Cheon; +34 Authors
Mohamed Abdulkadir; Dongmei Yu; Lisa Osiecki; Robert A. King; Thomas V. Fernandez; Lawrence W. Brown; Keun-Ah Cheon; Barbara J. Coffey; Blanca Garcia-Delgar; Donald L. Gilbert; Dorothy E. Grice; Julie Hagstrøm; Tammy Hedderly; Isobel Heyman; Hyun Ju Hong; Chaim Huyser; Laura Ibanez-Gomez; Young Key Kim; Young-Shin Kim; Yun-Joo Koh; Sodahm Kook; Samuel Kuperman; Bennett Leventhal; Marcos Madruga-Garrido; Athanasios Maras; Pablo Mir; Astrid Morer; Alexander Münchau; Kerstin J. Plessen; Veit Roessner; Eun-Young Shin; Dong-Ho Song; Jungeun Song; Frank Visscher; Samuel H. Zinner; Carol A. Mathews; Jeremiah M. Scharf; Jay A. Tischfield; Gary A. Heiman; Andrea Dietrich; Pieter J. Hoekstra;
Investigation of gene–environment interactions in relation to tic severity
AbstractTourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive–compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene–environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene–environment studies.
- TU Dresden Germany
- University of Iowa United States
- University of Copenhagen Denmark
- Rutgers, The State University of New Jersey United States
- University of Mary United States
Polimorfismo de nucleótido simple, Autism Spectrum Disorder, Autism, Neurodegenerative, Severity of Illness Index, Attention Deficit Disorder with Hyperactivity/genetics; Autism Spectrum Disorder/genetics; Female; Gene-Environment Interaction; Genome-Wide Association Study; Humans; Pregnancy; Severity of Illness Index; Tics; Tourette Syndrome; Gene–environment interaction; Pre- and perinatal complications; Tic severity; Tourette syndrome, Pregnancy, 2.1 Biological and endogenous factors, Psychology, Predicción, Aetiology, Pediatric, Tics*, Pre- and perinatal complications, Serious Mental Illness, Mental Health, Nucleótidos, Sitios genéticos, Tics, Mental health, Female, Tic severity, Intellectual and Developmental Disabilities (IDD), 610, Attention Deficit Disorder with Hyperactivity* / genetics, Genetics, Humans, Gene–environment interaction, Metaanálisis, Neurotransmisores, Neurology & Neurosurgery, Autism Spectrum Disorder* / genetics, Tourette syndrome, Human Genome, Psychiatry and Preclinical Psychiatric Studies - Original Article, Neurosciences, Tourette Syndrome*, Trastorno obsesivo compulsivo, Gene-environment interaction, Brain Disorders, Genes, Attention Deficit Disorder with Hyperactivity, Gene-Environment Interaction, Trastorno del espectro autista, Síndrome de Tourette, Genome-Wide Association Study, Tourette Syndrome
Polimorfismo de nucleótido simple, Autism Spectrum Disorder, Autism, Neurodegenerative, Severity of Illness Index, Attention Deficit Disorder with Hyperactivity/genetics; Autism Spectrum Disorder/genetics; Female; Gene-Environment Interaction; Genome-Wide Association Study; Humans; Pregnancy; Severity of Illness Index; Tics; Tourette Syndrome; Gene–environment interaction; Pre- and perinatal complications; Tic severity; Tourette syndrome, Pregnancy, 2.1 Biological and endogenous factors, Psychology, Predicción, Aetiology, Pediatric, Tics*, Pre- and perinatal complications, Serious Mental Illness, Mental Health, Nucleótidos, Sitios genéticos, Tics, Mental health, Female, Tic severity, Intellectual and Developmental Disabilities (IDD), 610, Attention Deficit Disorder with Hyperactivity* / genetics, Genetics, Humans, Gene–environment interaction, Metaanálisis, Neurotransmisores, Neurology & Neurosurgery, Autism Spectrum Disorder* / genetics, Tourette syndrome, Human Genome, Psychiatry and Preclinical Psychiatric Studies - Original Article, Neurosciences, Tourette Syndrome*, Trastorno obsesivo compulsivo, Gene-environment interaction, Brain Disorders, Genes, Attention Deficit Disorder with Hyperactivity, Gene-Environment Interaction, Trastorno del espectro autista, Síndrome de Tourette, Genome-Wide Association Study, Tourette Syndrome
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP!influenceInfluence provided by BIP!
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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