Aim of the work. To evaluate the course of acute coronary syndrome in patients depending on the applied method of treatment and the formation of the components of the internal picture of health in the process of treatment and rehabilitation. Material and methods. The object of the study was 141 patients with ACS with ST elevation. The patients were divided into groups depending on the performed treatment: 63 patients who received conservative treatment tactics and 78 patients who had PCI. The course of ACS was analyzed, depending on the treatment tactics, on clinical-anamnestic and objective data, using psychometric techniques. Results. Estimation of the formation of components of the internal picture of health was performed on the basis of the ACS course analysis. There were low levels for all components, the lowest was the level according to the behavioral and value-motivational components. In patients with PCI, these levels were somewhat higher according to some indices. The importance of the application of evaluation and correction of the IPH components in patients after ACS was determined. Conclusions. In order to increase the effectiveness of restorative treatment of patients after ACS, it is necessary to evaluate the formation of components of IPH with optimization by participating in the “Program of clinical-psychological rehabilitation of patients by optimization of IPH”, which would allow us to influence the positive changes in the course of the disease.