In order to solve the contradiction between error detection, transmission rate and system resources in data transmission of ultra-precision measurement, a kind of algorithm for high-speed generating CRC code has been put forward in this paper. Theoretical formulae for calculating CRC code of 16-bit segmented data are obtained by derivation. On the basis of 16-bit segmented data formulae, Optimized algorithm for 32-bit segmented data CRC coding is obtained, which solve the contradiction between memory occupancy and coding speed. Data coding experiments are conducted triumphantly by using high-speed ARM embedded system. The results show that this method has features of high error detecting ability, high speed and saving system resources, which improve Real-time Performance and Reliability of the measurement data communication.