Prognostic significance of smac/DIABLO in endometrioid endometrial cancer.
Copyright policy )Prognostic significance of smac/DIABLO in endometrioid endometrial cancer.
Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrial pathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examined smac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantified by Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors. Smac/DIABLO expression significantly correlated with tumor grade (p<0.001). Patients with positive smac/DIABLO tumors had a longer disease-specific survival when compared with those with negative tumors in the 10-year follow-up (p=0.043). The study demonstrated that negative smac/DIABLO expression was a poor prognostic sign.
- Wrocław Medical University Poland
- Medical University of Białystok Poland
Intracellular signaling peptides and proteins - metabolism, QH573-671, Intracellular Signaling Peptides and Proteins, Endometrial neoplasms - mortality, endometrioid endometrial cancer, Endometrial neoplasms - diagnosis, Apoptosis, Middle Aged, Prognosis, Immunohistochemistry, Endometrial Neoplasms, Mitochondrial Proteins, Mitochondrial proteins - metabolism, smac/DIABLO, Humans, Female, prognosis, Middle aged, Cytology, Apoptosis Regulatory Proteins, Endometrial neoplasms - pathology, Aged
Intracellular signaling peptides and proteins - metabolism, QH573-671, Intracellular Signaling Peptides and Proteins, Endometrial neoplasms - mortality, endometrioid endometrial cancer, Endometrial neoplasms - diagnosis, Apoptosis, Middle Aged, Prognosis, Immunohistochemistry, Endometrial Neoplasms, Mitochondrial Proteins, Mitochondrial proteins - metabolism, smac/DIABLO, Humans, Female, prognosis, Middle aged, Cytology, Apoptosis Regulatory Proteins, Endometrial neoplasms - pathology, Aged
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).8 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!