The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes
Copyright policy )The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes
As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-d, as well as the process of nucleophilic substitution sulfonyloxy group of cysteine and cysteamine with the formation of compounds 5 and 6.
- FEDERAL STATE AUTONOMOUS EDUCATIONAL INSTITUTION OF HIGHER PROFESSIONAL EDUCATION NOTHERN (ARCTIC) FEDERAL UNIVERSITY Russian Federation
- Ural Federal University Russian Federation
биологически активные соединения, ANTIVIRAL DRUG, гетероциклы, TRIAZINE, БИОЛОГИЧЕСКИ АКТИВНЫЕ СОЕДИНЕНИЯ, антивирусные препараты, BIOLOGICAL ACTIVE COMPOUNDS, ТРИАЗИ, TRIAZAVERIN, biological active compounds; heterocycles; triazine; Triazaverin; antiviral drug, Chemistry, ГЕТЕРОЦИКЛЫ, триазаверин, ТРИАЗАВЕРИН, QD1-999, HETEROCYCLES, биологически активные соединения; гетероциклы; триазаверин; антивирусные препараты, АНТИВИРУСНЫЕ ПРЕПАРАТЫ
биологически активные соединения, ANTIVIRAL DRUG, гетероциклы, TRIAZINE, БИОЛОГИЧЕСКИ АКТИВНЫЕ СОЕДИНЕНИЯ, антивирусные препараты, BIOLOGICAL ACTIVE COMPOUNDS, ТРИАЗИ, TRIAZAVERIN, biological active compounds; heterocycles; triazine; Triazaverin; antiviral drug, Chemistry, ГЕТЕРОЦИКЛЫ, триазаверин, ТРИАЗАВЕРИН, QD1-999, HETEROCYCLES, биологически активные соединения; гетероциклы; триазаверин; антивирусные препараты, АНТИВИРУСНЫЕ ПРЕПАРАТЫ
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