As the CMOS technology scaling is facing fundamental issues, there has been a rise of novel beyond-CMOS technologies. Among those, several compute-in-memory technologies and quantum computing prominently stands out. For both of these classes of technologies, there is an urgent need of robust and efficient Electronic Design Automation (EDA) flows. In this research, several EDA challenges for the emerging technologies are addressed, including technology mapping, and logic synthesis for in-memory computing and quantum computing. Furthermore, a novel, native implementation of fuzzy logic on ReRAM devices has been practically demonstrated. Doctor of Philosophy