Expression of neural cell adhesion molecules and neurofilament protein isoforms in skeletal muscle tumors
Copyright policy )Expression of neural cell adhesion molecules and neurofilament protein isoforms in skeletal muscle tumors
In a series of rhabdomyosarcomas, the expression of neural cell adhesion molecules (NCAM) and neurofilament isoforms was probed in frozen sections. It was found that NCAM was widely expressed in rhabdomyosarcomas without relation to subtype or differentiation level. Neurofilament isoforms were found throughout all subtypes but were largely restricted to those neurofilament isoforms that are expressed early in neurogenesis, that is, poorly phosphorylated low- and medium-weight isoforms. It was concluded that the expression of these "neural" markers is widespread and does not signify a neural tumor.
- University of Groningen Netherlands
Adult, Male, Adolescent, Skeletal/metabolism, Immunoenzyme Techniques, Muscle Neoplasms/metabolism, Neurofilament Proteins, Rhabdomyosarcoma, Humans, Protein Isoforms, Preschool, Child, Muscle, Skeletal, Neural Cell Adhesion Molecules, Aged, Muscle Neoplasms, Rhabdomyosarcoma/metabolism, Infant, Newborn, Infant, Middle Aged, Newborn, Neurofilament Proteins/metabolism, Child, Preschool, Muscle, Neural Cell Adhesion Molecules/metabolism, Female
Adult, Male, Adolescent, Skeletal/metabolism, Immunoenzyme Techniques, Muscle Neoplasms/metabolism, Neurofilament Proteins, Rhabdomyosarcoma, Humans, Protein Isoforms, Preschool, Child, Muscle, Skeletal, Neural Cell Adhesion Molecules, Aged, Muscle Neoplasms, Rhabdomyosarcoma/metabolism, Infant, Newborn, Infant, Middle Aged, Newborn, Neurofilament Proteins/metabolism, Child, Preschool, Muscle, Neural Cell Adhesion Molecules/metabolism, Female
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