Background. The intravenous administration of tissue plasmongen activator within 4.5 h of the onset of acute ischaemic stroke is known to improve the treatment outcomes significantly. However, in 2015, five large studies simultaneously demonstrated the superiority of a mechanical revascularisation strategy over a drug-based approach. As a results of these studies, the updated guidelines, providing an advantage of mechanical thromboextraction.Aim. To evaluate the effectiveness of the combined system for mechanical thrombus extraction.Methods. We prepared a prototype of a combined system for mechanical thrombextraction in ischaemic stroke. We performed a trial on a laboratory animal in order to assess the efficiency of the system.Results. Our results show that mechanical thrombus extraction using the domestic prototype of the combined thrombextraction system was highly efficient. Complete restoration of blood flow was observed in the previously occluded segment.Conclusion. Our study demonstrated prototype of a combined system for mechanical thrombus extraction effectiveness in preclinical study. Received 10 December 2020. Revised 16 December 2020. Accepted 21 December 2020. Funding: The work is supported by a grant (project No. 056-00042-20-00). Conflict of interest: Authors declare no conflict of interest.