Abstract This study investigates the effect of 3D printing parameters on the tensile strength of the printed parts based on ASTM D638-14 standard. The samples were fabricated using Fused Deposition Modeling (FDM) technology using polyethylene terephthalate glycol (PETG) material with different printing conditions. A series of tensile tests were performed to determine the tensile strength of the samples produced with different processing parameters. The test results show that the mechanical properties of the 3D printed parts using PETG material are greatly affected by the printing speed, layer thickness and these parameters tended to be inversely proportional to the tensile strength. The results are the cornerstone for the selection of suitable 3D printing parameters for predicting the tensile strength of the sample depending on the expected load of the manufactured parts and the appropriate expected printing time.