Abstract How do different types of regional organizations react to current challenges and crises? This special issue of the Politische Vierteljahresschrift explores this question by bringing together contributions from European Union studies and comparative regionalism. This introduction discusses the concepts of crisis, adaptation, and resilience as well as the value of the dialogue between the two subdisciplines, outlines the aims of the special issue, systematizes the main findings of the contributions, and reflects on their implications for future research.